Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 10/20 | 0.37 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.37 |
| ▸ | CDK2 | P24941 | 9/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 9/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | TOP2A | P11388 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8826177 | 0.88 | SLC29A1 (0.47) | MAP3K5CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL432160 | 0.84 | PAK1 (0.48) | MAP3K5CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL130799 | 0.81 | MAP3K5 (0.56) | MAP3K5CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL13742847 | 0.80 | HSP90AA1 (0.35) | MAP3K5PIN1POLBCYP2C19ALDH1A1 | |
| SCHEMBL13742759 | 0.80 | MAP3K5 (0.35) | MAP3K5PIN1POLBCYP2C19ALDH1A1 | |
| SCHEMBL21316654 | 0.80 | MAP3K5 (0.38) | MAP3K5CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL2359623 | 0.80 | CYP1A2 (0.40) | MAP3K5CDK1CCNB1CCNA2CDK2 | |
| SCHEMBL9346521 | 0.80 | MAP3K5 (0.41) | MAP3K5CDK2PIN1POLBCYP2C19 | |
| SCHEMBL3305050 | 0.79 | PIN1 (0.48) | PIN1POLBCYP2C19ALDH1A1CYP1A2 | |
| SCHEMBL17663669 | 0.79 | SLC29A1 (0.36) | MAP3K5CDK1CCNB1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200061062-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | ICOS CORPORATION | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200061062-A1 | INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA | PIK3CD, PIK3CA, PIK3CG | MAP3K5 122/4885CDK1 199/4885CCNB1 927/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.