Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 18/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.38 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.37 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.37 |
| ▸ | ACVRL1 | P37023 | 6/20 | 0.35 |
| ▸ | ACVR1B | P36896 | 6/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3390023 | 0.89 | TGFBR1 (0.40) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL247224 | 0.87 | TBK1 (0.46) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL3379333 | 0.87 | IDO1 (0.39) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL3383241 | 0.87 | TGFBR1 (0.38) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL12440185 | 0.86 | TGFBR1 (0.41) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL3390252 | 0.85 | TGFBR1 (0.40) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL3392992 | 0.83 | TGFBR1 (0.39) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL244421 | 0.83 | KDR (0.47) | TGFBR1IDO1PIM1FLT3PIM3 | |
| SCHEMBL3383905 | 0.82 | TGFBR1 (0.41) | TGFBR1IDO1PIM1FLT3PIM3 | |
| Hydrochloric Acid SCHEMBL14877110 | 0.82 | TGFBR1 (0.39) | TGFBR1IDO1PIM1FLT3PIM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585461-B1 | 2,4-DIARYL-SUBSTITUTED [1,8]NAPHTHYRIDINES AS KINASE INHIBITORS FOR USE AGAINST CANCER | MERCK PATENT GMBH (DE) | 2020-02-26 | — | — | EP | disclosed |