SCHEMBL21756770

SCHEMBL21756770

COc1ccc(NC(=O)C(=N)/N=C\N)cc1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 1/20 0.53
IMPDH1 P20839 1/20 0.53
CYP1A2 P05177 2/20 0.49
CYP2C19 P33261 2/20 0.49
CYP2C9 P11712 1/20 0.49
KMT2A Q03164 5/20 0.47
SMN1; SMN2 Q16637 4/20 0.47
RAB9A P51151 4/20 0.47
KDM4E B2RXH2 3/20 0.47
NPC1 O15118 2/20 0.47
MEN1 O00255 4/20 0.47
ALDH1A1 P00352 2/20 0.47
TP53 P04637 2/20 0.47
MAPT P10636 2/20 0.47
POLB P06746 3/20 0.46
GAA P10253 2/20 0.46
ALOX15 P16050 1/20 0.46
MAPK1 P28482 1/20 0.46
HSD17B10 Q99714 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5032606 0.77 MAPT (0.55) CYP1A2CYP2C19CYP2C9KMT2ASMN1; SMN2
SCHEMBL5032613 0.77 MAPT (0.55) CYP1A2CYP2C19CYP2C9KMT2ASMN1; SMN2
SCHEMBL15682833 0.75 IMPDH2 (0.68) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL15338460 0.75 IMPDH2 (0.67) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL1184403 0.74 KMT2A (0.57) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL7760777 0.74 CYP1A2 (0.65) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL21756771 0.73 KIF11 (0.49) KMT2ASMN1; SMN2RAB9AKDM4ENPC1
SCHEMBL20938764 0.73 IMPDH2 (0.53) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL4100667 0.73 SMN1; SMN2 (0.56) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9
SCHEMBL7166437 0.73 KMT2A (0.60) IMPDH2IMPDH1CYP1A2CYP2C19CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020041556-A1 N-SUBSTITUTED-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDES, ANALOGUES THEREOF, AND METHODS OF TREATMENT USING SAME THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) 2020-02-27 WO disclosed