Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2172957 | 0.85 | PIK3CA (0.53) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL30290797 | 0.82 | KDM4E (0.51) | ALPLKDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL2173919 | 0.79 | GPBAR1 (0.44) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2171308 | 0.79 | PIK3CA (0.53) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2172385 | 0.77 | KDM4E (0.39) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2173092 | 0.77 | PIK3CA (0.44) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2171484 | 0.77 | POLB (0.49) | PIK3CAKMT2ATP53MAPTPOLB | |
| SCHEMBL2172245 | 0.76 | TP53 (0.41) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2173329 | 0.76 | GPBAR1 (0.47) | ALPLKDM4EALDH1A1HSD17B10PIK3CA | |
| SCHEMBL2171482 | 0.76 | KDM4E (0.59) | ALPLKDM4EALDH1A1HSD17B10KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346832-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | Glaxo Group Limited (GB) | 2011-07-27 | — | — | EP | claimed |
| WO-2010049366-A1 | TRICYCLIC COMPOUNDS AS GLUTAMATE RECEPTOR MODULATORS | GLAXO GROUP LIMITED (GB) | 2010-05-06 | — | — | WO | claimed |