Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21756924 | 0.84 | GABRA1 (0.41) | GABRA1GABRB2GABRB1TTR | |
| SCHEMBL17402434 | 0.78 | AHR (0.37) | GABRA1GABRB2AHRBCL2BCL2L1 | |
| SCHEMBL19695773 | 0.78 | CA9 (0.39) | GABRA1GABRB2AHRBCL2BCL2L1 | |
| SCHEMBL21765276 | 0.77 | GABRA1 (0.35) | GABRA1GABRB2GABRB1 | |
| SCHEMBL21756930 | 0.77 | GABRA1 (0.35) | GABRA1GABRB2GABRB1BCL2BCL2L1 | |
| SCHEMBL24248982 | 0.77 | SELL (0.48) | GABRA1GABRB2AHRBCL2BCL2L1 | |
| SCHEMBL1349867 | 0.76 | GABRA1 (0.38) | GABRA1GABRB2GABRB1TTR | |
| SCHEMBL27033289 | 0.75 | GABRA1 (0.43) | GABRA1GABRB2GABRB1AHRBCL2 | |
| SCHEMBL21765277 | 0.75 | GABRA1 (0.34) | GABRA1GABRB2GABRB1 | |
| SCHEMBL21769673 | 0.75 | GABRA1 (0.34) | GABRA1GABRB2GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020039088-A2 | NOVEL COMPOUNDS | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039092-A2 | NOVEL AROMATIC MOLECULES | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| WO-2020039094-A1 | PHENOXY(HETERO)ARYL ETHERS OF ANTIPROLIFERATIVE ACTIVITY | Xeniopro GmbH (DE) | 2020-02-27 | — | — | WO | disclosed |
| US-9403829-B2 | Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino [2,3-b]pyrazin-2(1H)-one, a solid form thereof and methods of their use | SIGNAL PHARMACEUTICALS, LLC (US) | 2016-08-02 | — | — | US | disclosed |