SCHEMBL21758632

SCHEMBL21758632

Cc1ccccn1.FC(F)(F)c1ccc(Cl)c(Cl)c1Cl

nearest known ligand 0.50

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
GRM4 Q14833 2/20 0.41
LMNA P02545 2/20 0.37
ALDH1A1 P00352 1/20 0.37
P2RX7 Q99572 8/20 0.37
HSD11B1 P28845 1/20 0.36
POLB P06746 2/20 0.36
MEN1 O00255 1/20 0.36
MAPT P10636 1/20 0.36
KMT2A Q03164 1/20 0.36
CLCN2 P51788 1/20 0.35
OPRK1 P41145 1/20 0.34
KCNN4 O15554 1/20 0.34
SLC40A1 Q9NP59 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
2-Chloropyridine SCHEMBL28307609 0.84 TDP1 (0.53) GRM4LMNAALDH1A1P2RX7POLB
Pyridine SCHEMBL21878250 0.78 CLCN2 (0.39) GRM4LMNAALDH1A1P2RX7CLCN2
SCHEMBL30524329 0.77 NOTUM (0.41) LMNAP2RX7CLCN2
SCHEMBL2991016 0.77 NOTUM (0.41) LMNAP2RX7CLCN2
SCHEMBL29472848 0.71
SCHEMBL16322907 0.71 KDM4E (0.50) LMNAALDH1A1POLBMEN1KMT2A
SCHEMBL2684 0.71
SCHEMBL29599136 0.71 KDM4E (0.50) LMNAALDH1A1POLBMEN1KMT2A
SCHEMBL4733426 0.71 KDM4E (0.50) LMNAALDH1A1POLBMEN1KMT2A
SCHEMBL4148183 0.70 KDM4E (0.56) GRM4LMNAALDH1A1MEN1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10577326-B1 Method for preparing 2-chloro-6-trichloromethylpyridine through liquid phase photochlorination of 2-methylpyridine Zhejiang Avilive Chemical, Co., Ltd. (CN) 2020-03-03 US disclosed