Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.43 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.43 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.43 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.40 |
| ▸ | KCNK10 | P57789 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22092478 | 0.85 | RXFP1 (0.46) | RXFP1KDM4ELMNAPOLBKCNK2 | |
| SCHEMBL29259910 | 0.85 | KDM4E (0.63) | KDM4EHSD17B10HSP90AA1HSP90AB1SERPINE1 | |
| SCHEMBL24269577 | 0.83 | ATR (0.53) | RXFP1KDM4EHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL17378665 | 0.83 | CYP1A2 (0.51) | KDM4EHSD17B10RAB9ATP53MAPT | |
| SCHEMBL2472815 | 0.82 | RAB9A (0.53) | KDM4EHSD17B10SERPINE1PDK1PDK2 | |
| SCHEMBL30572402 | 0.82 | RAB9A (0.53) | KDM4EHSD17B10SERPINE1PDK1PDK2 | |
| SCHEMBL3787046 | 0.81 | KMT2A (0.54) | HSP90AA1HSP90AB1PDK1PDK2PDK3 | |
| SCHEMBL8257605 | 0.81 | PDK1 (0.51) | KDM4EHSD17B10SERPINE1PDK1PDK2 | |
| SCHEMBL17616117 | 0.80 | KMT2A (0.52) | RXFP1HSP90AA1HSP90AB1RAB9AMAPT | |
| SCHEMBL6628806 | 0.80 | PDK1 (0.56) | HSP90AA1HSP90AB1PDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3548469-B1 | METHOD FOR THE MANUFACTURE OF EFAVIRENZ | UNIV NELSON MANDELA METROPOLITAN (ZA) | 2020-08-26 | — | — | EP | claimed |
| US-10689353-B2 | Method for the manufacture of Efavirenz | NELSON MANDELA METROPOLITAN UNIVERSITY (ZA) | 2020-06-23 | — | — | US | disclosed |
| US-20200062722-A1 | Method For The Manufacture of Efavirenz | NELSON MANDELA METROPOLITAN UNIVERSITY (ZA) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10689353-B2 | Method for the manufacture of Efavirenz | CYP2F1, CYP2D6, CYP3A4 | RXFP1 3961/4885KDM4E 334/4885HSD17B10 519/4885 |
| US-20200062722-A1 | Method For The Manufacture of Efavirenz | CYP2F1, CYP2D6, CYP3A4 | RXFP1 3961/4885KDM4E 334/4885HSD17B10 519/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.