Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.55 |
| ▸ | MMP1 | P03956 | 2/20 | 0.55 |
| ▸ | MMP3 | P08254 | 1/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.55 |
| ▸ | FDPS | P14324 | 13/20 | 0.48 |
| ▸ | GGPS1 | O95749 | 7/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4311511 | 0.77 | MCL1 (0.47) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL2730881 | 0.74 | MCL1 (0.48) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL2836345 | 0.73 | MCL1 (0.44) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL5987745 | 0.72 | MCL1 (0.47) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL9205480 | 0.72 | MMP2 (0.56) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL6313039 | 0.72 | MCL1 (0.42) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL18330274 | 0.72 | FDPS (0.58) | MMP2MMP1FDPSGGPS1PDE3A | |
| SCHEMBL127951 | 0.72 | MEN1 (0.55) | MMP2MMP1FDPSGGPS1PDE3A | |
| SCHEMBL21307803 | 0.71 | MCL1 (0.45) | MMP2MMP1MMP3MMP9MCL1 | |
| SCHEMBL20928420 | 0.71 | MCL1 (0.45) | MMP2MMP1MMP3MMP9MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3371203-B1 | BORTEZOMIB CONJUGATES AND METHODS USING SAME | UNIV ROCHESTER (US) | 2020-02-26 | — | — | EP | disclosed |