Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15830635 | 0.84 | DRD2 (0.50) | DRD2DRD4DRD3KCNH2CSNK1D | |
| SCHEMBL15824627 | 0.78 | MAPK14 (0.46) | DRD2DRD4DRD3KCNH2CSNK1D | |
| SCHEMBL3478611 | 0.78 | KDM2B (0.54) | DRD2DRD4DRD3MAPK14KDM4E | |
| SCHEMBL30716678 | 0.75 | DRD2 (0.43) | DRD2DRD4DRD3KCNH2CSNK1D | |
| SCHEMBL28770418 | 0.73 | KDM2B (0.46) | DRD2DRD4DRD3KCNH2MAPK14 | |
| SCHEMBL15824772 | 0.72 | KDM2B (0.49) | DRD2DRD4DRD3GRM2CSNK1D | |
| SCHEMBL30716653 | 0.72 | MAPK1 (0.46) | DRD2DRD4DRD3KDM2BTP53 | |
| SCHEMBL20391435 | 0.71 | CCR1 (0.43) | TGFBR1DRD2DRD4DRD3MAPK14 | |
| SCHEMBL17077311 | 0.71 | GRIN2B (0.43) | DRD2DRD4DRD3NPC1RAB9A | |
| SCHEMBL17077315 | 0.71 | GRIN2B (0.43) | DRD2DRD4DRD3NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265454-B1 | TGF-BETA INHIBITORS | RIGEL PHARMACEUTICALS INC (US) | 2020-02-26 | — | — | EP | disclosed |