SCHEMBL2176015

SCHEMBL2176015

O=C(O)c1ccccc1C(O)O

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.59
ALOX15 P16050 2/20 0.59
GAA P10253 1/20 0.55
KMT2A Q03164 1/20 0.55
TDP1 Q9NUW8 1/20 0.55
MAPT P10636 3/20 0.54
HDAC8 Q9BY41 1/20 0.54
KDM4E B2RXH2 3/20 0.50
HPGD P15428 2/20 0.50
CA12 O43570 2/20 0.50
CA1 P00915 2/20 0.50
CA2 P00918 2/20 0.50
CA4 P22748 2/20 0.50
CA7 P43166 2/20 0.50
CA9 Q16790 2/20 0.50
HMGB1 P09429 1/20 0.50
CA6 P23280 1/20 0.50
SMN1; SMN2 Q16637 1/20 0.50
NAPRT Q6XQN6 1/20 0.50
CA14 Q9ULX7 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11602789 0.88 ALDH1A1 (0.62) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL900830 0.83 ALDH1A1 (0.68) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL15197918 0.83 ALDH1A1 (0.50) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL2955775 0.82 ALDH1A1 (0.54) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL134091 0.81 ALDH1A1 (0.59) ALDH1A1ALOX15GAAKMT2ATDP1
Hydrogen Peroxide SCHEMBL9514730 0.81 ALDH1A1 (0.59) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL29657201 0.81 ALDH1A1 (0.59) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL254364 0.81 ALDH1A1 (0.59) ALDH1A1ALOX15GAAKMT2ATDP1
Benzene SCHEMBL28132022 0.81 ALDH1A1 (0.59) ALDH1A1ALOX15GAAKMT2ATDP1
SCHEMBL13123149 0.80 AKR1C3 (0.57) ALDH1A1GAAKMT2ATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11220650-B2 Grease composition SHELL OIL COMPANY (US) 2022-01-11 US claimed
US-11198830-B2 Grease composition SHELL OIL COMPANY (US) 2021-12-14 US claimed
EP-4680706-A1 BIODEGRADABLE GREASE COMPOSITION Shell Internationale Research Maatschappij B.V. (NL) 2026-01-21 EP disclosed
EP-3692121-B1 GREASE COMPOSITION SHELL INT RESEARCH (NL) 2023-07-19 EP disclosed
WO-2023111683-A1 N4-HYDROXYCYTIDINE DERIVATIVES AND USE THEREOF AS ANTIVIRAL AGENT ASCLETIS BIOSCIENCE CO., LTD. (CN) 2023-06-22 WO disclosed
US-11318129-B2 Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders ARDELYX, INC. (US) 2022-05-03 US disclosed
CN-110023464-B Grease composition 国际壳牌研究有限公司 2022-02-08 CN disclosed
US-11220650-B2 Grease composition SHELL OIL COMPANY (US) 2022-01-11 US disclosed
US-11198830-B2 Grease composition SHELL OIL COMPANY (US) 2021-12-14 US disclosed
EP-2785821-B1 GREASE COMPOSITION SHELL INT RESEARCH (NL) 2021-03-03 EP disclosed
US-20200268741-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS ARDELYX, INC. (US) 2020-08-27 US disclosed
EP-1404335-A1 AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS Astrazeneca AB (SE) 2004-04-07 EP disclosed
CN-1131252-C Acrylic-modified waterborne alkyd or urethane-modified alkyd dispersions EASTMAN CHEM CO (US) 2003-12-17 CN disclosed
WO-2003000267-A1 AMINO NICOTINATE DERIVATIVES AS GLUCOKINASE (GLK) MODULATORS ASTRAZENECA AB (SE) 2003-01-03 WO disclosed
CN-1388412-A Photo sensitive composition and negative lithographic printing plate FUJI PHOTO FILM CO LTD (JP) 2003-01-01 CN disclosed
US-20020146633-A1 FLUORINATED AROMATIC ACETAL POLYMERS AND PHOTOSENSITIVE COMPOSITIONS CONTAINING SUCH POLYMERS KODAK POLYCHROME GRAPHICS L.L.C. 2002-10-10 US disclosed
US-6458503-B1 BLEND WITH DIAZO RESIN; LITHOGRAPHIC PRINTING PLATES; PHOTOPOLYMERIZATION AND CROSSLINKING KODAK POLYCHROME GRAPHICS LLC 2002-10-01 US disclosed
WO-2002073315-A1 FLUORINATED AROMATIC ACETAL POLYMERS AND PHOTOSENSITIVE COMPOSITIONS CONTAINING SUCH POLYMERS KODAK POLYCHROME GRAPHICS COMPANY, LTD. (US) 2002-09-19 WO disclosed
CN-1365368-A Acrylic modified waterborne alkyd or uralkyd dispersions EASTMAN CHEM CO (US) 2002-08-21 CN disclosed
US-4051078-A CURING DAINICHI-NIPPON CABLES, LTD. (JA) 1977-09-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11318129-B2 Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid retention or salt overload and gastrointestinal tract disorders SLC10A1, SLC10A2, FABP3 ALDH1A1 2512/4885ALOX15 1374/4885GAA 1585/4885
US-20200268741-A1 COMPOUNDS AND METHODS FOR INHIBITING NHE-MEDIATED ANTIPORT IN THE TREATMENT OF DISORDERS ASSOCIATED WITH FLUID RETENTION OR SALT OVERLOAD AND GASTROINTESTINAL TRACT DISORDERS SLC10A1, SLC10A2, FABP3 ALDH1A1 2512/4885ALOX15 1374/4885GAA 1585/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.