Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21760774 | 0.87 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRGLAL3MBTL1LMNA | |
| SCHEMBL21761043 | 0.85 | SMN1; SMN2 (0.38) | SMN1; SMN2TSHRGLAL3MBTL1LMNA | |
| SCHEMBL15822237 | 0.83 | HTR2A (0.38) | SMN1; SMN2TSHRGLAL3MBTL1KDM4E | |
| SCHEMBL23585316 | 0.82 | SMN1; SMN2 (0.40) | SMN1; SMN2TSHRGLAL3MBTL1LMNA | |
| SCHEMBL21760980 | 0.81 | SMN1; SMN2 (0.37) | SMN1; SMN2TSHRGLAL3MBTL1LMNA | |
| SCHEMBL23585513 | 0.78 | SMN1; SMN2 (0.36) | SMN1; SMN2TSHRGLAL3MBTL1LMNA | |
| SCHEMBL21189843 | 0.78 | KDM4E (0.40) | SMN1; SMN2TSHRGLAL3MBTL1KDM4E | |
| SCHEMBL21761024 | 0.75 | MAOB (0.41) | SMN1; SMN2GLAKDM4EGAAALDH1A1 | |
| SCHEMBL21761052 | 0.75 | PTGS1 (0.33) | MAPTPTGDR2 | |
| SCHEMBL23585393 | 0.75 | HTR2A (0.45) | SMN1; SMN2TSHRGLAL3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842439-A1 | BICYCLIC HETEROAROMATIC RING DERIVATIVE | Kyorin Pharmaceutical Co., Ltd. (JP) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020040104-A1 | BICYCLIC HETEROAROMATIC RING DERIVATIVE | 杏林製薬株式会社 | 2020-02-27 | — | — | WO | disclosed |