Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.31 |
| ▸ | CHRNG | P07510 | 1/20 | 0.31 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.31 |
| ▸ | CHRND | Q07001 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2964904 | 0.75 | HCAR3 (0.37) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL2964902 | 0.75 | HCAR3 (0.37) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL14576457 | 0.71 | HCAR3 (0.35) | HCAR3HCAR2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL2176282 | 0.69 | RORC (0.33) | HCAR3HCAR2CHRNA1CHRNGCHRNB1 | |
| SCHEMBL7581890 | 0.66 | CHRNA1 (0.37) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL17707721 | 0.64 | HCAR3 (0.39) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL17707720 | 0.64 | HCAR3 (0.39) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL21981814 | 0.64 | HCAR3 (0.39) | HCAR3HCAR2HSD11B1CHRNA1CHRNG | |
| SCHEMBL29031880 | 0.59 | HCAR3 (0.44) | HCAR3HCAR2ALDH1A1MEN1KMT2A | |
| SCHEMBL30472345 | 0.59 | HCAR3 (0.44) | HCAR3HCAR2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110218194-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | Schering Corporation & Pharmacopeia Drug Discovery Inc. (US) | 2011-09-08 | — | — | US | disclosed |
| US-7973067-B2 | Heterocyclic aspartyl protease inhibitors | SCHERING CORPORATION (US) | 2011-07-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110218194-A1 | HETEROCYCLIC ASPARTYL PROTEASE INHIBITORS | CHRM1, CHRM2, PRSS1 | HCAR3 1751/4885HCAR2 2333/4885HSD11B1 1571/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.