Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 1/20 | 0.73 |
| ▸ | PKM | P14618 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | AKT1 | P31749 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | CASP6 | P55212 | 1/20 | 0.53 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11893082 | 0.87 | ALDH1A1 (0.77) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL28693374 | 0.85 | ALDH1A1 (0.94) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL26453 | 0.84 | ALDH1A1 (1.00) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL1094305 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL2178229 | 0.83 | ALDH1A1 (0.71) | ALDH1A1LMNAPKMHPGDAKT1 | |
| Sulfamethizole SCHEMBL1566142 | 0.83 | ALDH1A1 (0.97) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL5183445 | 0.82 | ALDH1A1 (0.70) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL18077365 | 0.82 | ALDH1A1 (1.00) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL11891715 | 0.82 | ALDH1A1 (0.69) | ALDH1A1LMNAPKMHPGDAKT1 | |
| SCHEMBL286629 | 0.81 | ALDH1A1 (0.71) | ALDH1A1LMNAPKMHPGDAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | CD274, PDCD1LG2, PDCD1 | ALDH1A1 380/4885LMNA 4797/4885PKM 2285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.