Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 2/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7906136 | 0.85 | HTR2C (0.46) | GSK3AGSK3BEHMT2HTR2CBRD4 | |
| SCHEMBL18114398 | 0.80 | SLC6A2 (0.46) | GSK3AGSK3BEHMT2HCRTR1HCRTR2 | |
| SCHEMBL18127406 | 0.80 | SLC6A2 (0.46) | GSK3AGSK3BEHMT2HCRTR1HCRTR2 | |
| SCHEMBL1914402 | 0.79 | GSK3A (0.43) | GSK3AGSK3BEHMT2HTR2CHCRTR1 | |
| SCHEMBL17793378 | 0.79 | GSK3A (0.50) | GSK3AGSK3BEHMT2BRD4HCRTR1 | |
| SCHEMBL2025086 | 0.79 | GSK3A (0.43) | GSK3AGSK3BEHMT2HTR2CHCRTR1 | |
| SCHEMBL19468800 | 0.79 | GSK3A (0.50) | GSK3AGSK3BEHMT2BRD4HCRTR1 | |
| SCHEMBL21538655 | 0.78 | LMNA (0.50) | EHMT2BRD4HCRTR1HCRTR2MEN1 | |
| SCHEMBL18114452 | 0.78 | MEN1 (0.42) | GSK3AGSK3BEHMT2HCRTR1HCRTR2 | |
| SCHEMBL2246337 | 0.78 | GSK3A (0.47) | GSK3AGSK3BEHMT2BRD4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3799870-A1 | IRE-1A INHIBITORS | Fosun Orinove Pharmatech, Inc. (CN) | 2021-04-07 | — | — | EP | disclosed |
| EP-3409276-B1 | IRE-1A INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-12-30 | — | — | EP | disclosed |
| EP-2496230-B1 | IRE-1 ALPHA INHIBITORS | FOSUN ORINOVE PHARMATECH INC (CN) | 2020-02-26 | — | — | EP | disclosed |