Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20348900 | 0.80 | GSK3A (0.47) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL21763648 | 0.78 | GSK3A (0.45) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL21563281 | 0.78 | GSK3A (0.53) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL21563349 | 0.78 | GSK3A (0.53) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL17793378 | 0.75 | GSK3A (0.50) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL19468800 | 0.75 | GSK3A (0.50) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL31495430 | 0.74 | HPGD (0.51) | GSK3AGSK3BKMT2AALDH1A1BRD4 | |
| SCHEMBL21538655 | 0.74 | LMNA (0.50) | EHMT2MEN1KMT2AALDH1A1SMO | |
| SCHEMBL23058167 | 0.72 | HDAC2 (0.58) | GSK3AGSK3BEHMT2MEN1KMT2A | |
| SCHEMBL28547806 | 0.72 | L3MBTL1 (0.48) | GSK3AGSK3BMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951709-B1 | IMIDAZOLIDINONE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (US) | 2012-07-18 | — | — | EP | disclosed |
| US-8003653-B2 | Imidazolidinone compounds useful as β-secretase inhibitors for the treatment of Alzheimer's disease | Merck. Sharp & Dohme Corp. (US) | 2011-08-23 | — | — | US | disclosed |
| US-20090111832-A1 | Imidazolidinone Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LLC | 2009-04-30 | — | — | US | disclosed |
| EP-1951709-A2 | IMIDAZOLIDINONE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | Merck & Co., Inc. (US) | 2008-08-06 | — | — | EP | disclosed |
| WO-2007058862-A2 | IMIDAZOLIDINONE COMPOUNDS USEFUL AS BETA-SECRETASE INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | MERCK & CO., INC. (US) | 2007-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111832-A1 | Imidazolidinone Compounds Useful as Beta-Secretase Inhibitors for the Treatment of Alzheimer's Disease | BACE1, BACE2, PSEN1 | GSK3A 147/4885GSK3B 97/4885EHMT2 2339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.