Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 6/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.52 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.52 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17213024 | 0.90 | PABPC1 (0.55) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL18540543 | 0.90 | NPC1 (0.52) | NPC1RAB9ACASP3SENP8SENP7 | |
| SCHEMBL17213099 | 0.73 | NPC1 (0.51) | NPC1RAB9APOLBPARP1ALDH1A1 | |
| SCHEMBL17213001 | 0.73 | RAB9A (0.46) | NPC1RAB9APOLBALDH1A1KMT2A | |
| SCHEMBL17212996 | 0.72 | SIRT2 (0.52) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL17213100 | 0.72 | NR1H4 (0.48) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL18540510 | 0.72 | KMT2A (0.53) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL18540535 | 0.71 | SMN1; SMN2 (0.49) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL17213061 | 0.71 | NPC1 (0.50) | NPC1RAB9APOLBALDH1A1MAPT | |
| SCHEMBL17212991 | 0.71 | GRK6 (0.44) | NPC1RAB9APOLBPARP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3134390-B1 | SMALL MOLECULE INHIBITORS OF G PROTEIN COUPLED RECEPTOR 6 KINASE POLYPEPTIDES | MAYO FOUND MEDICAL EDUCATION & RES (US) | 2020-02-26 | — | — | EP | disclosed |