Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HHAT | Q5VTY9 | 7/20 | 1.00 |
| ▸ | LHCGR | P22888 | 3/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6848473 | 0.85 | HHAT (0.74) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL3365755 | 0.85 | HHAT (0.73) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL20912495 | 0.82 | HHAT (0.70) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL3367746 | 0.82 | HHAT (0.69) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL3365878 | 0.80 | HHAT (0.67) | HHATLHCGR | |
| SCHEMBL3366099 | 0.80 | HHAT (0.67) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL7885827 | 0.80 | LHCGR (0.67) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL7885995 | 0.80 | HHAT (0.66) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL3365448 | 0.80 | HHAT (0.66) | HHATLHCGRMAPK1NPSR1 | |
| SCHEMBL7891893 | 0.80 | HHAT (0.66) | HHATLHCGRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200062776-A1 | HEDGEHOG ACYLTRANSFERASE INHIBITORS AND USES THEREOF | HHAT, SHH, MBOAT1 | HHAT 1/4885LHCGR 2397/4885MAPK1 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.