SCHEMBL21764057

SCHEMBL21764057

NC1=CC(c2ccccc2)CC(c2cccc3ccccc23)=C1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 1/20 0.42
CYP19A1 P11511 2/20 0.36
FGFR1 P11362 1/20 0.34
FGFR2 P21802 1/20 0.34
ALDH1A1 P00352 1/20 0.33
CYP3A4 P08684 1/20 0.33
HPGD P15428 1/20 0.33
TSHR P16473 1/20 0.33
KEAP1 Q14145 1/20 0.33
HSD17B10 Q99714 1/20 0.33
DHFR P00374 1/20 0.33
EDNRB P24530 1/20 0.32
EDNRA P25101 1/20 0.32
PTPN1 P18031 1/20 0.32
HRH3 Q9Y5N1 1/20 0.32
HTR1A P08908 2/20 0.32
HTR7 P34969 2/20 0.32
TGFBR1 P36897 1/20 0.32
FABP7 O15540 1/20 0.31
NOS3 P29474 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23656341 0.77 CFTR (0.35) SLC6A3ALDH1A1CYP3A4HSD17B10HTR1A
SCHEMBL24737116 0.74 SLC6A3 (0.42) SLC6A3ALDH1A1CYP3A4HSD17B10DHFR
SCHEMBL18405208 0.64 SLC6A3 (0.37) SLC6A3ALDH1A1HTR1AHTR7NISCH
SCHEMBL7166811 0.63 SLC6A3 (0.44) SLC6A3ALDH1A1CYP3A4HPGDTSHR
Benzene SCHEMBL28202246 0.63 ALDH1A1 (0.56) ALDH1A1CYP3A4HPGDTSHRKEAP1
SCHEMBL29521589 0.63 ALDH1A1 (0.65) ALDH1A1CYP3A4HPGDTSHRKEAP1
SCHEMBL56035 0.63 ALDH1A1 (0.65) ALDH1A1CYP3A4HPGDTSHRKEAP1
SCHEMBL1681365 0.63 SLC6A3 (0.46) SLC6A3ALDH1A1CYP3A4HPGDTSHR
SCHEMBL1718299 0.61 ALDH1A1 (0.62) ALDH1A1CYP3A4HPGDTSHRKEAP1
SCHEMBL4922363 0.61 ALDH1A1 (0.62) ALDH1A1CYP3A4HPGDTSHRKEAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3369737-B1 ORGANOMETALLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE ORGANOMETALLIC COMPOUND, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND SAMSUNG ELECTRONICS CO LTD (KR) 2020-02-26 EP disclosed