Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | CSF1R | P07333 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | CDK8 | P49336 | 1/20 | 0.31 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.31 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21765777 | 0.80 | PTGS2 (0.36) | — | |
| SCHEMBL21747227 | 0.72 | PCSK9 (0.35) | PCSK9 | |
| SCHEMBL21747417 | 0.70 | EGLN1 (0.37) | PCSK9 | |
| SCHEMBL21747303 | 0.70 | ALDH1A1 (0.40) | PCSK9 | |
| SCHEMBL21747254 | 0.69 | ALDH1A1 (0.39) | — | |
| SCHEMBL21747383 | 0.67 | EGLN1 (0.35) | PCSK9MAP2K1DYRK1B | |
| SCHEMBL21747414 | 0.67 | EGLN1 (0.40) | — | |
| SCHEMBL6445284 | 0.66 | PCSK9 (0.41) | PCSK9CHEK1MAP4K4CSF1RPRKACA | |
| SCHEMBL21747421 | 0.65 | EGLN1 (0.37) | — | |
| Formamide SCHEMBL28739639 | 0.61 | ATM (0.52) | PCSK9ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3613742-A1 | INDOLIZINE DERIVATIVES AND APPLICATION THEREOF IN MEDICINE | Kind Pharmaceutical (CN) | 2020-02-26 | — | — | EP | disclosed |