Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | HTR6 | P50406 | 6/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.51 |
| ▸ | EEF2K | O00418 | 1/20 | 0.51 |
| ▸ | PLK4 | O00444 | 1/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.51 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 1/20 | 0.51 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.51 |
| ▸ | CDK2 | P24941 | 1/20 | 0.51 |
| ▸ | AKT1 | P31749 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7826186 | 0.84 | HTR6 (0.67) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| SCHEMBL2177227 | 0.83 | KMT2A (0.55) | LMNASMN1; SMN2KMT2AMEN1ALDH1A1 | |
| SCHEMBL11798939 | 0.81 | LMNA (0.60) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| SCHEMBL7824422 | 0.80 | HTR6 (0.61) | CYP2C19HTR6LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL7835318 | 0.79 | HTR6 (0.72) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| Sulfamonomethoxine SCHEMBL93784 | 0.78 | CYP2C19 (1.00) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| SCHEMBL1136475 | 0.78 | HTR6 (0.52) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| Sulfamonomethoxine SCHEMBL29362359 | 0.78 | CYP2C19 (1.00) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| SCHEMBL2176380 | 0.78 | MAPT (0.68) | CYP2C19HTR6LMNASMN1; SMN2KMT2A | |
| Sulfamonomethoxine SCHEMBL11052075 | 0.77 | CYP2C19 (0.97) | CYP2C19HTR6LMNASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2013-01-24 | — | — | US | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
| WO-2011082400-A2 | MODULATORS OF IMMUNOINHIBITORY RECEPTOR PD-1, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130022629-A1 | Modulators of Immunoinhibitory Receptor PD-1, and Methods of Use Thereof | CD274, PDCD1LG2, PDCD1 | CYP2C19 2798/4885HTR6 1173/4885LMNA 4797/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.