Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.37 |
| ▸ | CLK1 | P49759 | 3/20 | 0.37 |
| ▸ | CLK2 | P49760 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2178733 | 0.91 | MKNK1 (0.48) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2178583 | 0.90 | CCNT1 (0.45) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2179774 | 0.89 | CLK4 (0.50) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2179735 | 0.87 | ACP1 (0.44) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2178948 | 0.86 | DYRK1A (0.48) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2177853 | 0.86 | CCNT1 (0.46) | CLK4DYRK1AKDM4EALDH1A1LMNA | |
| SCHEMBL2178358 | 0.86 | CASR (0.42) | MKNK1CLK4LMNAAURKAGSK3B | |
| SCHEMBL2177434 | 0.86 | VNN1 (0.42) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2179118 | 0.86 | PRKD3 (0.39) | HDAC3NCOR1HDAC2MKNK1CLK4 | |
| SCHEMBL2180425 | 0.86 | HDAC3 (0.44) | HDAC3NCOR1HDAC2MKNK1CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | HDAC3 1641/4885NCOR1 418/4885HDAC2 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.