Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2179735 | 0.93 | ACP1 (0.44) | HPGDKDM4EALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL2179774 | 0.88 | CLK4 (0.50) | KDM4EKMT2ADYRK1ACLK4DYRK1B | |
| SCHEMBL2178911 | 0.88 | CASR (0.39) | HPGDKDM4EALDH1A1HSD17B10CYP1A2 | |
| SCHEMBL2178948 | 0.88 | DYRK1A (0.48) | DYRK1ACLK4DYRK1BMKNK1MAPK13 | |
| SCHEMBL2176860 | 0.86 | HDAC3 (0.38) | KDM4EALDH1A1GAADYRK1ACLK4 | |
| SCHEMBL2177386 | 0.85 | HDAC3 (0.49) | KDM4EALDH1A1HSD17B10CYP1A2GLA | |
| SCHEMBL2178733 | 0.85 | MKNK1 (0.48) | CYP2D6DYRK1ACLK4DYRK1BMKNK1 | |
| SCHEMBL2178193 | 0.85 | DYRK1A (0.47) | KDM4EALDH1A1GAAKMT2ADYRK1A | |
| SCHEMBL2178583 | 0.84 | CCNT1 (0.45) | KDM4EDYRK1ACLK4DYRK1BMKNK1 | |
| SCHEMBL2178358 | 0.84 | CASR (0.42) | CYP1A2CYP3A4CYP2D6CLK4MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | VNN1 1700/4885HPGD 225/4885KDM4E 2457/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.