Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.33 |
| ▸ | CPB1 | P15086 | 1/20 | 0.32 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.32 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.31 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.31 |
| ▸ | ERAP2 | Q6P179 | 2/20 | 0.31 |
| ▸ | ERAP1 | Q9NZ08 | 2/20 | 0.31 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28378561 | 1.00 | GSR (0.37) | GSRTHRBALOX15BLMPMP22 | |
| Histidine SCHEMBL9220370 | 0.96 | GSR (0.40) | GSRTHRBALOX15BLMPMP22 | |
| Histidine SCHEMBL9211892 | 0.96 | GSR (0.40) | GSRTHRBALOX15BLMPMP22 | |
| Histidine SCHEMBL10379722 | 0.93 | ALOX15 (0.40) | GSRALOX15BLMPMP22KMT2A | |
| Histidine SCHEMBL9750903 | 0.93 | ALOX15 (0.40) | GSRALOX15BLMPMP22KMT2A | |
| Histidine SCHEMBL14691272 | 0.92 | GSR (0.40) | GSRTHRBSLC7A5CPB1CPB2 | |
| Histidine SCHEMBL14690885 | 0.92 | GSR (0.40) | GSRTHRBSLC7A5CPB1CPB2 | |
| Histidine SCHEMBL3791713 | 0.92 | GSR (0.36) | GSRTHRBALOX15BLMPMP22 | |
| Histidine SCHEMBL27806428 | 0.91 | ALOX15 (0.38) | GSRALOX15BLMPMP22KMT2A | |
| Histidine SCHEMBL9750989 | 0.91 | ALOX15 (0.38) | ALOX15BLMPMP22KMT2ASLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617314-A1 | OLIGONUCLEOTIDE DERIVATIVE OR SALT THEREOF | Kyowa Kirin Co., Ltd. (JP) | 2020-03-04 | — | — | EP | disclosed |