SCHEMBL21769786

SCHEMBL21769786

c1ccc(-c2nc3cccc(-c4ccc(-c5c6ccccc6c([Si](c6ccccc6)(c6ccccc6)c6ccccc6)c6ccccc56)cc4)c3n2-c2ccccc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
HSP90AA1 P07900 1/20 0.41
MAPT P10636 1/20 0.41
GAA P10253 2/20 0.40
ALDH1A1 P00352 11/20 0.38
HTT P42858 1/20 0.38
LMNA P02545 1/20 0.37
AKT1 P31749 2/20 0.36
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
RAB9A P51151 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MDM2 Q00987 1/20 0.35
POLB P06746 2/20 0.34
HCAR1 Q9BXC0 1/20 0.34
TSHR P16473 1/20 0.34
CYP2C19 P33261 1/20 0.34
PARP1 P09874 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24813308 0.83 MEN1 (0.43) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL15940256 0.82 ESR1 (0.49) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL21769606 0.80 MEN1 (0.43) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL24813311 0.77 MEN1 (0.44) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL14582722 0.77 ALDH1A1 (0.47) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL21769427 0.76 GAA (0.42) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL21769590 0.75 DHFR (0.41) MEN1KMT2AHSP90AA1MAPTALDH1A1
SCHEMBL18925706 0.74 MEN1 (0.46) MEN1KMT2AHSP90AA1MAPTGAA
SCHEMBL21769781 0.74 DHODH (0.44) MEN1KMT2AGAAALDH1A1RAB9A
SCHEMBL18021462 0.74 KMT2A (0.40) MEN1KMT2AHSP90AA1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020040434-A1 NOVEL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE USING SAME 주식회사 엘지화학 2020-02-27 WO disclosed