Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 14/20 | 0.70 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21753383 | 0.82 | P2RX7 (1.00) | P2RX7P2RY12MEN1KMT2AKDM4E | |
| SCHEMBL21753384 | 0.75 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL21753443 | 0.74 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL23949853 | 0.73 | P2RX7 (0.83) | P2RX7P2RY12MEN1KMT2AKDM4E | |
| SCHEMBL4885873 | 0.71 | P2RX7 (1.00) | P2RX7P2RY12 | |
| SCHEMBL14160433 | 0.71 | P2RX7 (0.64) | P2RX7P2RY12MEN1KMT2AKDM4E | |
| SCHEMBL21769578 | 0.71 | P2RX7 (0.72) | P2RX7P2RY12TYK2 | |
| SCHEMBL14160451 | 0.69 | P2RX7 (0.64) | P2RX7P2RY12MAPTTYK2 | |
| SCHEMBL23950059 | 0.68 | P2RX7 (0.67) | P2RX7P2RY12 | |
| SCHEMBL14160475 | 0.68 | P2RX7 (0.59) | P2RX7P2RY12MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020037350-A1 | ADAMANTANYL-SUBSTITUTED BENZAMIDE COMPOUNDS AND THEIR USE AS P2X7 RECEPTOR ANTAGONISTS | THE UNIVERSITY OF SYDNEY (AU) | 2020-02-27 | — | — | WO | disclosed |