Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 3/20 | 0.33 |
| ▸ | FDPS | P14324 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22818931 | 1.00 | JAK2 (0.37) | JAK2JAK1ACHEFDPS | |
| SCHEMBL21953544 | 0.95 | JAK2 (0.37) | JAK2JAK1ACHE | |
| SCHEMBL22794193 | 0.85 | ACHE (0.42) | JAK2JAK1ACHE | |
| SCHEMBL25882662 | 0.81 | ACHE (0.33) | ACHE | |
| SCHEMBL19407150 | 0.80 | JAK2 (0.36) | JAK2JAK1ACHE | |
| SCHEMBL26546592 | 0.78 | JAK2 (0.42) | JAK2JAK1ACHE | |
| SCHEMBL22393858 | 0.76 | L3MBTL1 (0.49) | ACHE | |
| SCHEMBL23634026 | 0.75 | JAK2 (0.43) | JAK2JAK1 | |
| SCHEMBL24253220 | 0.72 | CYP19A1 (0.39) | — | |
| SCHEMBL15431451 | 0.72 | ACHE (0.41) | ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452475-B1 | TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS SA (ES) | 2020-02-26 | — | — | EP | disclosed |