Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 4/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.32 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.31 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.31 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | GUSB | P08236 | 2/20 | 0.31 |
| ▸ | EBP | Q15125 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19564599 | 1.00 | GNAI3 (0.36) | GNAI3GNAO1GNAI1LMNAOPRM1 | |
| SCHEMBL18733270 | 0.79 | SLC6A4 (0.37) | LMNAOPRM1DNM1 | |
| SCHEMBL22375268 | 0.77 | CHRM2 (0.33) | CHRM2CHRM3 | |
| SCHEMBL20387047 | 0.76 | GNAI3 (0.33) | GNAI3GNAO1GNAI1LMNAOPRM1 | |
| SCHEMBL22375275 | 0.70 | — | — | |
| SCHEMBL21346792 | 0.70 | POLB (0.35) | LMNA | |
| Dodecane SCHEMBL28162032 | 0.70 | TSHR (0.53) | GNAI3GNAO1GNAI1LMNADNM1 | |
| SCHEMBL24997853 | 0.69 | LMNA (0.34) | LMNAOPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL22460117 | 0.69 | GNAI3 (0.50) | GNAI3GNAO1GNAI1SIGMAR1GUSB | |
| SCHEMBL19710610 | 0.69 | GNAI3 (0.50) | GNAI3GNAO1GNAI1SIGMAR1GUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452475-B1 | TETRAHYDROPYRIMIDODIAZEPINE AND TETRAHYDROPYRIDODIAZEPINE COMPOUNDS FOR TREATING PAIN AND PAIN RELATED CONDITIONS | ESTEVE PHARMACEUTICALS SA (ES) | 2020-02-26 | — | — | EP | disclosed |