Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 2/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21771187 | 1.00 | SLC6A4 (0.39) | SLC6A4LMNAMEN1KMT2ATHRB | |
| SCHEMBL12865461 | 0.91 | LMNA (0.40) | SLC6A4LMNAMEN1KMT2ATHRB | |
| SCHEMBL12865465 | 0.91 | LMNA (0.40) | SLC6A4LMNAMEN1KMT2ATHRB | |
| SCHEMBL22794309 | 0.88 | TSHR (0.46) | SLC6A4MEN1KMT2ATHRBHTT | |
| SCHEMBL4633781 | 0.88 | LMNA (0.37) | SLC6A4LMNAMEN1KMT2AHTT | |
| SCHEMBL24765691 | 0.86 | MEN1 (0.45) | SLC6A4MEN1KMT2ATHRBHTT | |
| SCHEMBL18827613 | 0.86 | DNM1 (0.44) | SLC6A4TSHRS1PR2S1PR1S1PR3 | |
| SCHEMBL13961055 | 0.84 | KDM4C (0.39) | SLC6A4ALDH1A1S1PR2S1PR1S1PR3 | |
| SCHEMBL4396255 | 0.83 | TSHR (0.50) | SLC6A4MEN1KMT2ATHRBHTT | |
| SCHEMBL24061839 | 0.83 | HTR1D (0.38) | SLC6A4LMNAMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020041331-A1 | PROTEOLYSIS TARGETING CHIMERIC (PROTAC) COMPOUND WITH E3 UBIQUITIN LIGASE BINDING ACTIVITY AND TARGETING ALPHA-SYNUCLEIN PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES | ARVINAS OPERATIONS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |