Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | NOX1 | Q9Y5S8 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 4/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17289246 | 0.77 | SNCA (0.83) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL29640485 | 0.76 | MAPT (0.59) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL225916 | 0.76 | MAPT (0.59) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL8256707 | 0.71 | PARP10 (0.53) | MAOBALDH1A1 | |
| SCHEMBL24255127 | 0.71 | MAPT (0.50) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL20325528 | 0.71 | MAOB (0.53) | TDP1MAOBSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2756476 | 0.70 | NOX1 (0.53) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL12431902 | 0.69 | MAOB (0.52) | TDP1NPC1RAB9AMAOBSLC6A2 | |
| SCHEMBL239549 | 0.69 | NOX1 (0.65) | SNCAMAPTMEN1KMT2ANOX1 | |
| SCHEMBL8352183 | 0.69 | SLC6A2 (0.63) | LMNAL3MBTL1EPHX2ALDH1A1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020041331-A1 | PROTEOLYSIS TARGETING CHIMERIC (PROTAC) COMPOUND WITH E3 UBIQUITIN LIGASE BINDING ACTIVITY AND TARGETING ALPHA-SYNUCLEIN PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES | ARVINAS OPERATIONS, INC. (US) | 2020-02-27 | — | — | WO | disclosed |