Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17294310 | 1.00 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL17294316 | 0.94 | CA1 (0.47) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL1918364 | 0.81 | L3MBTL1 (0.46) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL1397437 | 0.79 | NPC1 (0.45) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL8433568 | 0.78 | KDM4E (0.49) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL13545147 | 0.76 | PTGS1 (0.44) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL2764882 | 0.75 | KDM4E (0.50) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL14809035 | 0.75 | KDM4E (0.58) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL2565281 | 0.75 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2LMNACA1 | |
| SCHEMBL13543202 | 0.75 | NPC1 (0.42) | NPC1RAB9ASMN1; SMN2LMNACA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973047-B2 | Beta-Secretase modulators and methods of use | AMGEN INC. (US) | 2011-07-05 | — | — | US | disclosed |
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. | 2010-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222338-A1 | BETA-SECRETASE MODULATORS AND METHODS OF USE | BACE1, BACE2, APP | NPC1 1381/4885RAB9A 1585/4885SMN1; SMN2 1679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.