Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 8/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | TLR4 | O00206 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1188324 | 0.94 | NPC1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL1981599 | 0.92 | CA1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL1978465 | 0.92 | CA1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL28365490 | 0.92 | CA1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL9079832 | 0.82 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL1918364 | 0.81 | L3MBTL1 (0.46) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL2431325 | 0.80 | NPC1 (0.58) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL13545147 | 0.80 | PTGS1 (0.44) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL2013833 | 0.80 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 | |
| SCHEMBL2013836 | 0.80 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2LMNAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283550-B1 | CATALYST CONTAINING AMIDINE GROUPS | SIKA TECH AG (CH) | 2020-12-16 | — | — | EP | disclosed |
| EP-3294803-B1 | GUANIDINE GROUP CONTAINING CATALYST | SIKA TECH AG (CH) | 2020-12-09 | — | — | EP | disclosed |
| CN-107428941-B | Amidino group-containing catalyst | SIKA技术股份公司 | 2020-11-24 | — | — | CN | disclosed |
| CN-107735438-B | Guanidino-containing catalysts | SIKA技术股份公司 | 2020-06-09 | — | — | CN | disclosed |
| US-10414875-B2 | Catalyst containing guanidine groups | SIKA TECHNOLOGY AG (CH) | 2019-09-17 | — | — | US | disclosed |
| US-10392480-B2 | Catalyst containing amidine groups | SIKA TECHNOLOGY AG (CH) | 2019-08-27 | — | — | US | disclosed |
| EP-2288640-B1 | WATER SOLUBLE AMINE AND ITS APPLICATION | SIKA TECH AG (CH) | 2018-09-19 | — | — | EP | disclosed |
| US-20180171082-A1 | CATALYST CONTAINING AMIDINE GROUPS | SIKA TECHNOLOGY AG (CH) | 2018-06-21 | — | — | US | disclosed |
| US-20180148545-A1 | CATALYST CONTAINING GUANIDINE GROUPS | SIKA TECHNOLOGY AG (CH) | 2018-05-31 | — | — | US | disclosed |
| EP-3294803-A1 | CATALYST CONTAINING GUANIDINE GROUPS | Sika Technology AG (CH) | 2018-03-21 | — | — | EP | disclosed |
| EP-2288639-A1 | POLYAMINE HAVING A REDUCED BLUSHING EFFECT, AND USE THEREOF AS A CURING AGENT FOR EPOXY RESINS | Sika Technology AG (CH) | 2011-03-02 | — | — | EP | disclosed |
| EP-2288640-A1 | WATER-SOLUBLE AMINE AND USES THEREOF | Sika Technology AG (CH) | 2011-03-02 | — | — | EP | disclosed |
| WO-2010039982-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010039982-A1 | CRTH2 MODULATORS | IRONWOOD PHARMACEUTICALS, INC. (US) | 2010-04-08 | — | — | WO | disclosed |
| WO-2009150212-A1 | WATER-SOLUBLE AMINE AND USES THEREOF | SIKA TECHNOLOGY AG (CH) | 2009-12-17 | — | — | WO | disclosed |
| WO-2009150219-A1 | POLYAMINE HAVING A REDUCED BLUSHING EFFECT, AND USE THEREOF AS A CURING AGENT FOR EPOXY RESINS | SIKA TECHNOLOGY AG (CH) | 2009-12-17 | — | — | WO | disclosed |
| EP-2133378-A1 | Polyamine with reduced blushing and its application as hardener for epoxy resin | Sika Technology AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| EP-2133381-A1 | Water soluble amine and its application | Sika Technology AG (CH) | 2009-12-16 | — | — | EP | disclosed |
| US-7332492-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
| US-7332492-B2 | Amino substituted dibenzothiophene derivatives for the treatment of disorders mediated by NP Y5 receptor | ASTRAZENECA AB (SE) | 2008-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10414875-B2 | Catalyst containing guanidine groups | GMPS, GMNN, RNMT | NPC1 3733/4885RAB9A 1813/4885SMN1; SMN2 172/4885 |
| US-20180148545-A1 | CATALYST CONTAINING GUANIDINE GROUPS | GMPS, RNMT, GMNN | NPC1 3631/4885RAB9A 1485/4885SMN1; SMN2 194/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.