Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 14/20 | 0.77 |
| ▸ | CSF1R | P07333 | 11/20 | 0.77 |
| ▸ | KDR | P35968 | 11/20 | 0.77 |
| ▸ | FLT3 | P36888 | 10/20 | 0.77 |
| ▸ | FLT4 | P35916 | 6/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | MET | P08581 | 4/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.58 |
| ▸ | KIT | P10721 | 2/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1099958 | 0.87 | FLT4 (1.00) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL2174495 | 0.85 | PDGFRB (0.83) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL1099350 | 0.84 | FLT4 (0.92) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL5610690 | 0.83 | PDGFRB (0.61) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL1097432 | 0.82 | FLT4 (0.89) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL1098995 | 0.82 | FLT4 (0.89) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL2175642 | 0.81 | CSF1R (0.69) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL22104148 | 0.81 | PDGFRA (0.74) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL21301531 | 0.81 | MET (0.85) | PDGFRBCSF1RKDRFLT3FLT4 | |
| SCHEMBL31324673 | 0.81 | MET (0.85) | PDGFRBCSF1RKDRFLT3FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | claimed |