Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 16/20 | 0.61 |
| ▸ | CSF1R | P07333 | 13/20 | 0.61 |
| ▸ | FLT3 | P36888 | 10/20 | 0.61 |
| ▸ | FLT4 | P35916 | 6/20 | 0.61 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.46 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177325 | 0.83 | PDGFRB (0.77) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5598910 | 0.77 | PDGFRB (0.68) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5598979 | 0.76 | CSF1R (0.64) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5610715 | 0.75 | SMN1; SMN2 (0.55) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5599019 | 0.75 | PDGFRB (0.64) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5598429 | 0.74 | PDGFRB (0.65) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL5598949 | 0.74 | PDGFRB (0.70) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL2174495 | 0.74 | PDGFRB (0.83) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL1099958 | 0.73 | FLT4 (1.00) | PDGFRBCSF1RFLT3FLT4KDR | |
| SCHEMBL2177123 | 0.73 | PDGFRB (0.86) | PDGFRBCSF1RFLT3FLT4KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007113565-A1 | NAPHTHYRIDINE DERIVATIVES AS ANTI-CANCER AGENTS | ASTRAZENECA AB (SE) | 2007-10-11 | — | — | WO | disclosed |