Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.38 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | CLK1 | P49759 | 3/20 | 0.37 |
| ▸ | CLK2 | P49760 | 2/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2177434 | 0.88 | VNN1 (0.42) | MKNK1DYRK1ACLK4DYRK1BMAPK13 | |
| SCHEMBL2179774 | 0.88 | CLK4 (0.50) | MKNK1DYRK1ACLK4DYRK1BMAPK13 | |
| SCHEMBL2178948 | 0.87 | DYRK1A (0.48) | CASRMKNK1DYRK1ACLK4DYRK1B | |
| SCHEMBL2178358 | 0.87 | CASR (0.42) | CASRMKNK1CLK4MTNR1AMTNR1B | |
| SCHEMBL2176860 | 0.85 | HDAC3 (0.38) | MKNK1DYRK1ACLK4DYRK1BRAF1 | |
| SCHEMBL2177386 | 0.85 | HDAC3 (0.49) | MKNK1DYRK1ACLK4DYRK1BHDAC3 | |
| SCHEMBL2178733 | 0.84 | MKNK1 (0.48) | MKNK1DYRK1ACLK4DYRK1BHDAC3 | |
| SCHEMBL2179735 | 0.84 | ACP1 (0.44) | MKNK1DYRK1ACLK4DYRK1BRAF1 | |
| SCHEMBL2178193 | 0.84 | DYRK1A (0.47) | MKNK1DYRK1ACLK4DYRK1BMAPK13 | |
| SCHEMBL2178583 | 0.84 | CCNT1 (0.45) | CASRMKNK1DYRK1ACLK4DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | ARQULE, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166137-A1 | Substituted Naphthalenyl-Pyrimidine Compounds | DPYD, TP53, TYMP | CASR 4176/4885MKNK1 2469/4885DYRK1A 2574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.