Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 9/20 | 0.66 |
| ▸ | FLT3 | P36888 | 8/20 | 0.66 |
| ▸ | FLT4 | P35916 | 3/20 | 0.66 |
| ▸ | CSF1R | P07333 | 6/20 | 0.62 |
| ▸ | MET | P08581 | 7/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | MERTK | Q12866 | 2/20 | 0.53 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.49 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.49 |
| ▸ | CACNA1I | Q9P0X4 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2176657 | 0.93 | PDGFRB (0.66) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2177123 | 0.85 | PDGFRB (0.86) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2174528 | 0.83 | FLT3 (0.64) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL1099080 | 0.80 | PDGFRB (1.00) | PDGFRBFLT3FLT4CSF1RKDR | |
| SCHEMBL2173233 | 0.78 | PDGFRB (0.86) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2175586 | 0.78 | MET (0.57) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2177267 | 0.77 | PDGFRB (0.83) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2175384 | 0.76 | FLT3 (0.64) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2172864 | 0.75 | KDR (0.63) | PDGFRBFLT3FLT4CSF1RMET | |
| SCHEMBL2174873 | 0.75 | KDR (0.70) | PDGFRBFLT3FLT4CSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | disclosed |
| US-20090076074-A1 | QUINOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090076074-A1 | QUINOLINE DERIVATIVES | RECQL, NQO2, CCNA1 | PDGFRB 2155/4885FLT3 251/4885FLT4 2418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.