Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.63 |
| ▸ | PDGFRB | P09619 | 8/20 | 0.63 |
| ▸ | FLT3 | P36888 | 5/20 | 0.63 |
| ▸ | CSF1R | P07333 | 5/20 | 0.63 |
| ▸ | MET | P08581 | 6/20 | 0.55 |
| ▸ | FLT4 | P35916 | 3/20 | 0.53 |
| ▸ | AXL | P30530 | 2/20 | 0.53 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | TEK | Q02763 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 5/20 | 0.49 |
| ▸ | KIT | P10721 | 4/20 | 0.49 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.49 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2175384 | 0.93 | FLT3 (0.64) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2174528 | 0.93 | FLT3 (0.64) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173631 | 0.92 | KDR (0.69) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173785 | 0.82 | PDGFRB (0.77) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL19957113 | 0.81 | KDR (0.63) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL4981120 | 0.80 | PDGFRB (0.65) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173091 | 0.80 | KDR (0.64) | KDRPDGFRBFLT3METFLT4 | |
| SCHEMBL5591960 | 0.78 | PDGFRB (0.56) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2173815 | 0.78 | MET (0.68) | KDRPDGFRBFLT3CSF1RMET | |
| SCHEMBL2177519 | 0.75 | PDGFRB (0.66) | KDRPDGFRBFLT3CSF1RMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7973164-B2 | Quinoline derivatives | ASTRAZENECA AB (SE) | 2011-07-05 | — | — | US | claimed |