SCHEMBL21775405

SCHEMBL21775405

O=C(O)N(C1CCN(C(=O)C(F)(F)F)CC1)[C@@H]1C[C@H]1c1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 4/20 0.57
RIPK1 Q13546 1/20 0.45
EPHX2 P34913 3/20 0.40
MAOA P21397 3/20 0.39
MAOB P27338 2/20 0.39
RBP4 P02753 2/20 0.39
SIGMAR1 Q99720 2/20 0.38
TACR1 P25103 2/20 0.37
HRH3 Q9Y5N1 1/20 0.36
RORC P51449 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21784423 0.86 KDM1A (0.50) KDM1ARIPK1TACR1RORC
SCHEMBL21784353 0.86 KDM1A (0.50) KDM1ARIPK1TACR1RORC
SCHEMBL19025342 0.86 KDM1A (0.50) KDM1ARIPK1TACR1RORC
SCHEMBL21784350 0.86 KDM1A (0.50) KDM1ARIPK1TACR1RORC
SCHEMBL28654372 0.77 KDM1A (0.50) KDM1ARIPK1MAOAMAOBTACR1
SCHEMBL19609126 0.77 MEN1 (0.49) TACR1RORC
SCHEMBL19025421 0.76 KDM1A (0.47) KDM1AMAOASIGMAR1HRH3
SCHEMBL23856027 0.75 KDM1A (0.43) KDM1AMAOAMAOBSIGMAR1
SCHEMBL18817699 0.75 KDM1A (0.43) KDM1AMAOAMAOBSIGMAR1
SCHEMBL28255285 0.75 KDM1A (0.43) KDM1AMAOAMAOBSIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2021-09-30 US disclosed
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2021-04-06 US disclosed
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2020-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A KDM1A 1/4885RIPK1 1898/4885EPHX2 2868/4885
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A KDM1A 1/4885RIPK1 1898/4885EPHX2 2868/4885
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A KDM1A 1/4885RIPK1 1898/4885EPHX2 2868/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.