SCHEMBL21784350

SCHEMBL21784350

CC(C)(C)OC(=O)N(C1CCN(C(=O)C(F)(F)F)CC1)[C@@H]1CC1c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
KDM1A O60341 1/20 0.50
GPR119 Q8TDV5 8/20 0.41
USP30 Q70CQ3 1/20 0.41
RORC P51449 1/20 0.41
TACR1 P25103 2/20 0.41
MEN1 O00255 3/20 0.40
KMT2A Q03164 3/20 0.40
RIPK1 Q13546 1/20 0.40
HSD11B1 P28845 1/20 0.40
JAK2 O60674 1/20 0.38
JAK1 P23458 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21784423 1.00 KDM1A (0.50) KDM1AGPR119USP30RORCTACR1
SCHEMBL21784353 1.00 KDM1A (0.50) KDM1AGPR119USP30RORCTACR1
SCHEMBL19025342 1.00 KDM1A (0.50) KDM1AGPR119USP30RORCTACR1
SCHEMBL20134529 0.86 SLC6A2 (0.42) KDM1AGPR119USP30HSD11B1
SCHEMBL21775405 0.86 KDM1A (0.57) KDM1ARORCTACR1RIPK1
SCHEMBL19609126 0.83 MEN1 (0.49) GPR119USP30RORCTACR1MEN1
SCHEMBL18845585 0.83 KDM1A (0.43) KDM1AHSD11B1JAK2JAK1
SCHEMBL23867772 0.82 GPR119 (0.41) GPR119HSD11B1
SCHEMBL19026233 0.81 KDM1A (0.46) KDM1AGPR119HSD11B1
SCHEMBL19025219 0.80 KDM1A (0.49) KDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2021-09-30 US disclosed
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2021-04-06 US disclosed
WO-2020047198-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION (US) 2020-03-05 WO disclosed
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2020-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A KDM1A 1/4885GPR119 1021/4885USP30 408/4885
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A KDM1A 1/4885GPR119 1021/4885USP30 408/4885
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A KDM1A 1/4885GPR119 1021/4885USP30 408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.