SCHEMBL21775417

SCHEMBL21775417

CC(C)(C)OC(=O)NS(=O)(=O)N1CC(=CC#N)C1

nearest known ligand 0.36

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSK P43235 3/20 0.36
CA12 O43570 4/20 0.35
CA14 Q9ULX7 4/20 0.35
CA1 P00915 2/20 0.35
CA7 P43166 2/20 0.35
CA2 P00918 1/20 0.35
CTSL P07711 2/20 0.33
CTSB P07858 2/20 0.33
CTSD P07339 1/20 0.33
CTSS P25774 1/20 0.33
EPAS1 Q99814 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21775400 0.78
SCHEMBL21784427 0.75 CTSK (0.38) CTSKCTSLCTSBCTSDCTSS
SCHEMBL29460254 0.73 CTSK (0.42) CTSKCA12CA14CA1CA7
SCHEMBL344121 0.72 USP2 (0.41) CTSK
SCHEMBL583414 0.71 CA12 (0.42) CTSKCA12CA14CA1CA7
SCHEMBL12792779 0.71 CA12 (0.42) CTSKCA12CA14CA1CA7
SCHEMBL29460248 0.71 CTSK (0.43) CTSKCA12CA14CA1CA7
SCHEMBL8276176 0.70 CA12 (0.41) CA12CA14CA1CA7CA2
SCHEMBL12421750 0.70 CA12 (0.45) CTSKCA12CA14CA1CA7
SCHEMBL24643192 0.70 CTSK (0.54) CTSKCA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11512064-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2022-11-29 US disclosed
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2021-09-30 US disclosed
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2021-09-30 US disclosed
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2021-04-06 US disclosed
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2021-04-06 US disclosed
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2020-03-05 US disclosed
WO-2020047198-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION (US) 2020-03-05 WO disclosed
WO-2020047198-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION (US) 2020-03-05 WO disclosed
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2020-03-05 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11512064-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A CTSK 3644/4885CA12 2498/4885CA14 3083/4885
US-20200071289-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A CTSK 3644/4885CA12 2498/4885CA14 3083/4885
US-20210300891-A1 SALTS OF AN LSD1 INHIBITOR AND PROCESSES FOR PREPARING THE SAME KDM1A, KDM1B, KDM2A CTSK 3644/4885CA12 2498/4885CA14 3083/4885
US-10968200-B2 Salts of an LSD1 inhibitor and processes for preparing the same KDM1A, KDM1B, KDM2A CTSK 3644/4885CA12 2498/4885CA14 3083/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.