Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.76 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.76 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.76 |
| ▸ | RET | P07949 | 5/20 | 0.76 |
| ▸ | FLT1 | P17948 | 4/20 | 0.76 |
| ▸ | FLT4 | P35916 | 4/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.76 |
| ▸ | KIT | P10721 | 3/20 | 0.76 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.76 |
| ▸ | ABL1 | P00519 | 3/20 | 0.76 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.76 |
| ▸ | STK10 | O94804 | 2/20 | 0.76 |
| ▸ | BCR | P11274 | 2/20 | 0.76 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.76 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.76 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.76 |
| ▸ | PTK6 | Q13882 | 2/20 | 0.76 |
| ▸ | DDR2 | Q16832 | 2/20 | 0.76 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.76 |
| ▸ | ERN1 | O75460 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1890089 | 0.93 | KDR (0.77) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL23366513 | 0.93 | KDR (0.83) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL19072630 | 0.92 | KDR (0.76) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL19957067 | 0.91 | KDR (0.75) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL19957141 | 0.91 | KDR (0.75) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL3503400 | 0.91 | KDR (0.64) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL22505669 | 0.91 | KDR (0.64) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL863668 | 0.91 | KDR (0.79) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL26726698 | 0.90 | KDR (0.73) | KDRPDGFRAAURKBRETFLT1 | |
| SCHEMBL23544752 | 0.90 | KDR (0.73) | KDRPDGFRAAURKBRETFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236050-B2 | Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2022-02-01 | — | — | US | disclosed |
| CN-113372270-A | Lunvatinib and preparation method thereof | 江西国药有限责任公司 | 2021-09-10 | — | — | CN | disclosed |
| US-20210188778-A1 | NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2021-06-24 | — | — | US | disclosed |
| CN-110283122-B | Preparation method of high-purity Lunvatinib and salt thereof | 石药集团中奇制药技术（石家庄）有限公司 | 2021-05-25 | — | — | CN | disclosed |
| US-10800741-B2 | Quinoline compound, preparation method and medical use therefor | ANCUREALL PHARMACEUTICAL (SHANGHAI) CO., LTD. (CN) | 2020-10-13 | — | — | US | disclosed |
| WO-2019111283-A1 | NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF | MSN LABORATORIES PRIVATE LIMITED, R&D CENTER (IN) | 2019-06-13 | — | — | WO | disclosed |
| US-7973160-B2 | Nitrogen-containing aromatic derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2011-07-05 | — | — | US | disclosed |
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2010-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197911-A1 | Nitrogen-Containing Aromatic Derivatives | GNG2, GCG, FRG1 | KDR 2687/4885PDGFRA 3131/4885AURKB 1909/4885 |
| US-11236050-B2 | Polymorphs of 4-[3-chloro-4-(n′-cyclopropyl ureido)phenoxy] -7-methoxyquinoline-6-carboxamide, its salts and process for the preparation thereof | UGT1A1, CYP4B1, CYP1B1 | KDR 4267/4885PDGFRA 1620/4885AURKB 3656/4885 |
| US-20210188778-A1 | NOVEL POLYMORPHS OF 4-[3-CHLORO-4-(N'-CYCLOPROPYL UREIDO)PHENOXY]-7-METHOXYQUINOLINE-6-CARBOXAMIDE, ITS SALTS AND PROCESS FOR THE PREPARATION THEREOF | CYP4B1, UGT1A1, CYP3A4 | KDR 4133/4885PDGFRA 1316/4885AURKB 3755/4885 |
| US-10800741-B2 | Quinoline compound, preparation method and medical use therefor | WEE2, WEE1, HASPIN | KDR 2448/4885PDGFRA 2993/4885AURKB 406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.