Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 3/20 | 0.46 |
| ▸ | PLA2G2C | Q5R387 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | KDM6B | O15054 | 1/20 | 0.42 |
| ▸ | KDM4A | O75164 | 1/20 | 0.42 |
| ▸ | KDM5A | P29375 | 1/20 | 0.42 |
| ▸ | MLYCD | O95822 | 1/20 | 0.39 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25705148 | 0.81 | CA12 (0.54) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL20665298 | 0.75 | L3MBTL1 (0.48) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL12892226 | 0.75 | KDM6B (0.50) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL4127134 | 0.72 | CA12 (0.71) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL5325386 | 0.72 | PLA2G2C (0.57) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL13780257 | 0.71 | L3MBTL1 (0.62) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL12972991 | 0.71 | L3MBTL1 (0.58) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL19755641 | 0.70 | FPR2 (0.50) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL5325383 | 0.70 | NAALAD2 (0.49) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C | |
| SCHEMBL19487325 | 0.68 | NAALAD2 (0.43) | L3MBTL1ALDH1A1LMNANAALAD2PLA2G2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11000515-B2 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | SHY Therapeutics LLC (US) | 2021-05-11 | — | — | US | disclosed |
| US-20200061037-A1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | SHY THERAPEUTICS, INC. | 2020-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11000515-B2 | Compounds that interact with the Ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease | HRAS, KRAS, NRAS | L3MBTL1 1677/4885ALDH1A1 3448/4885LMNA 3109/4885 |
| US-20200061037-A1 | COMPOUNDS THAT INTERACT WITH THE RAS SUPERFAMILY FOR THE TREATMENT OF CANCERS, INFLAMMATORY DISEASES, RASOPATHIES, AND FIBROTIC DISEASE | HRAS, KRAS, NRAS | L3MBTL1 1677/4885ALDH1A1 3448/4885LMNA 3109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.