Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Temafloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.60 |
| ▸ | FLT4 | P35916 | 1/20 | 0.60 |
| ▸ | RARB | P10826 | 1/20 | 0.60 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.60 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | XBP1 | P17861 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | TOP1 | P11387 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10902308 | 0.89 | KMT2A (0.72) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL34354 | 0.87 | KMT2A (1.00) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL9323984 | 0.87 | KMT2A (1.00) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL29383684 | 0.87 | KMT2A (1.00) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL34355 | 0.87 | KMT2A (1.00) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL3754459 | 0.87 | KMT2A (0.98) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL19149806 | 0.87 | KMT2A (0.98) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL9691106 | 0.87 | KMT2A (0.98) | KMT2AGSK3BEPHA2FLT4RARB | |
| Tosufloxacin SCHEMBL28308419 | 0.87 | KMT2A (0.98) | KMT2AGSK3BEPHA2FLT4RARB | |
| Temafloxacin SCHEMBL48095 | 0.87 | ALDH1A1 (0.61) | KMT2AGSK3BEPHA2FLT4RARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3820565-A1 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | Biovinc, LLC. (US) | 2021-05-19 | — | — | EP | disclosed |
| WO-2020014269-A9 | BISPHOSPHONATE QUINOLONE CONJUGATES AND USES THEREOF | BIOVINC, LLC. (US) | 2020-03-05 | — | — | WO | disclosed |