Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.58 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.56 |
| ▸ | PTPRF | P10586 | 1/20 | 0.50 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.50 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL628651 | 0.83 | CHRM2 (0.72) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| SCHEMBL21776818 | 0.83 | CHRM2 (0.58) | MAPTCHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL13527792 | 0.81 | PYCR1 (0.79) | CHRM2PYCR1MEN1KMT2ALOXL2 | |
| SCHEMBL1803792 | 0.80 | CHRM2 (0.64) | MAPTCHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL11597593 | 0.80 | CHRM2 (0.79) | CHRM2PTPRFPTPN2PTPN1PTPN11 | |
| Hydrochloric Acid SCHEMBL3168845 | 0.79 | PYCR1 (0.76) | MAPTCHRM2PYCR1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8365207 | 0.79 | CHRM2 (0.62) | MAPTCHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL1290510 | 0.77 | CHRM2 (0.70) | MAPTCHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL1041853 | 0.77 | MEN1 (0.69) | MAPTCHRM2PTPRFPTPN2PTPN1 | |
| SCHEMBL17187969 | 0.77 | CHRM2 (0.64) | MAPTCHRM2PTPRFPTPN2PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802108-B2 | Compounds for the modulation of cyclophilins function | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2023-10-31 | — | — | US | disclosed |
| US-11802108-B2 | Compounds for the modulation of cyclophilins function | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2023-10-31 | — | — | US | disclosed |
| US-11802108-B2 | Compounds for the modulation of cyclophilins function | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2023-10-31 | — | — | US | disclosed |
| US-20210238130-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2021-08-05 | — | — | US | disclosed |
| US-20210238130-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2021-08-05 | — | — | US | disclosed |
| EP-3843841-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | The University Court Of The University of Edinburgh (GB) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020043831-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2020-03-05 | — | — | WO | disclosed |
| WO-2020043831-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | THE UNIVERSITY COURT OF THE UNIVERSITY OF EDINBURGH (GB) | 2020-03-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11802108-B2 | Compounds for the modulation of cyclophilins function | CBR1, CBR3, PPIC | MAPT 2951/4885CHRM2 884/4885PYCR1 105/4885 |
| US-20210238130-A1 | COMPOUNDS FOR THE MODULATION OF CYCLOPHILINS FUNCTION | CBR1, CBR3, PPIC | MAPT 2951/4885CHRM2 884/4885PYCR1 105/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.