PPIC — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL14754020	0.92	1/20
SCHEMBL14754006	0.86	1/20
SCHEMBL14754003	0.83	1/20
SCHEMBL14753911	0.82	1/20
SCHEMBL17951008	0.81	1/20
SCHEMBL14753914	0.81	1/20
SCHEMBL14753966	0.81	1/20
SCHEMBL17951044	0.81	1/20
SCHEMBL14753930	0.81	1/20
SCHEMBL14753965	0.81	1/20
SCHEMBL17950969	0.81	1/20
SCHEMBL17951110	0.80	1/20
SCHEMBL17951009	0.80	1/20
SCHEMBL17951011	0.80	1/20
SCHEMBL17950960	0.80	1/20
SCHEMBL14753982	0.80	1/20
SCHEMBL14754017	0.79	1/20
SCHEMBL17951046	0.79	1/20
SCHEMBL14753990	0.78	1/20
SCHEMBL17950967	0.78	1/20

Clinical trials — most relevant to PPIC by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
A Phase III, Randomized, Study of Aspirin and Esomeprazole Chemoprevention in Barrett's Metaplasia	PHASE3	COMPLETED
Low-cost Enabling Technology for Image-guided Photodynamic Therapy (PDT) of Oral Cancer Cancer.	PHASE1/PHASE2	COMPLETED
Study Evaluating Toxicity & Efficacy of Lenalidomide(Revlimid®)in Chemotherapy-Naïve AIPC Patients	PHASE2	COMPLETED
Targeting Endoplasmic Reticulum Stress in Human Hypertension	PHASE1/PHASE2	RECRUITING
Safety and Pharmacology of SNX-5422 Plus Carboplatin and Paclitaxel in Subjects With Solid Tumors	PHASE1	COMPLETED
Study of Oral CNF2024 (BIIB021) in Advanced Solid Tumors	PHASE1	COMPLETED
SNX-5422 to Treat Solid Tumor Cancers and Lymphomas	PHASE1	COMPLETED
A Study on Psychopathological Progress of Early Schizophrenia-Like Disorder (SOPRES)	nan	UNKNOWN
Studies in Porphyria I: Characterization of Enzyme Defects	nan	UNKNOWN
Biomarkers in the Diagnosis and Prognosis of NAFLD	nan	RECRUITING
Expression of Markers Related to Mitochondrial Functionality in Carcinoma of the Urinary Bladder: Comparative Retrospective Analysis Between Recurrent Tumors (Non-responders) and Non-recurrent Tumors (Responders) After Intravesical Treatment With Chemotherapy or Immunotherapy	nan	UNKNOWN
Sensorimotor Gating in Schizophrenia	nan	COMPLETED
Plasma Cytochrome c as Biomarker of Traumatic Injury and Predictor of Outcome	nan	COMPLETED
IVF Outcome in Polycystic Ovary Syndrome Patients	nan	UNKNOWN
Genotype-supported Versus Conventional Proton Pump Inhibitor Dosing	nan	COMPLETED
Parkinson's Diseases Susceptibility Genes and Pesticides	nan	COMPLETED
Portable Measurement of Protoporphyrin IX in the Skin	nan	COMPLETED
Cerebellar Mutism Syndrome Study	nan	RECRUITING
Mitoferrin-1 Expression in Erythropoietic Protoporphyria (Porphyria Rare Disease Clinical Research Consortium (RDCRC))	nan	COMPLETED
Involvement of Endogenous Digitalis-like Compounds in Breast Cancer	nan	WITHDRAWN
Ovarian Reserve and Matrix Metalloproteinases	nan	COMPLETED
Role of Amino Acids and Genetic Disorder in Pathogenesis of Heart Failure	nan	UNKNOWN
Reducing Heart Failure Risk in Late-Life With Physical Activity	nan	NOT_YET_RECRUITING
Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA	nan	RECRUITING
Biomarkers in Idiopathic Juvenile Arthritis	nan	UNKNOWN
Identification of Genetic Markers Modulating Rhythmic Risk Among Patients With Severe Cardiomyopathy	nan	COMPLETED
Ischemic Preconditioning to Prevent Acute Kidney Injury	nan	COMPLETED
Pulmonary Hypertension, Hypoxia and Sickle Cell Disease	nan	COMPLETED
Proteomics to Identify Prognostic Markers After CPR and to Estimate Neurological Outcome	nan	COMPLETED
LIPCAR, Cuproptosis, and Α-SMA in the Pathogenesis of AMI and Remodeling	nan	NOT_YET_RECRUITING

Related proteins — ESM-2 sequence neighbours (a PPIC binder may also engage these)

Protein	Name	Similarity
Q08E11	—	1.000	Q08E11 →
P24369	—	0.998	P24369 →
P0CP79	—	0.991	P0CP79 →
P24368	—	0.990	P24368 →
Q9SP02	—	0.990	Q9SP02 →
Q27774	—	0.990	Q27774 →
P30412	—	0.990	P30412 →
Q26551	—	0.989	Q26551 →
P0CP78	—	0.989	P0CP78 →
P52013	—	0.989	P52013 →
Q8L8W5	—	0.989	Q8L8W5 →
O49605	—	0.988	O49605 →
B3A0R0	—	0.987	B3A0R0 →
P52014	—	0.987	P52014 →
Q5B4R3	—	0.986	Q5B4R3 →
Q26548	—	0.986	Q26548 →
Q9ZVJ4	—	0.986	Q9ZVJ4 →
P0C1I0	—	0.986	P0C1I0 →
P0C1H9	—	0.986	P0C1H9 →
Q0P5D0	—	0.986	Q0P5D0 →
P52009	—	0.984	P52009 →
P23285	—	0.984	P23285 →
Q8LDP4	—	0.984	Q8LDP4 →
PPIF	Peptidyl-prolyl cis-trans isomerase F, mitochondrial	0.983	landscape →
Q26994	—	0.983	Q26994 →
P80311	—	0.983	P80311 →
Q2UGK2	—	0.982	Q2UGK2 →
Q1RMP7	—	0.982	Q1RMP7 →
PPIH	Peptidyl-prolyl cis-trans isomerase H	0.982	landscape →
O93826	—	0.982	O93826 →