Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14997308 | 0.85 | TAAR1 (0.44) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL15319327 | 0.85 | TAAR1 (0.44) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL625240 | 0.85 | TAAR1 (0.44) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL29679614 | 0.85 | TAAR1 (0.44) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL15532117 | 0.85 | TRPA1 (0.58) | TAAR1ALOX15ALOX12IDO1PPARG | |
| SCHEMBL21777254 | 0.82 | TAAR1 (0.41) | TAAR1ALOX15ALOX12IDO1PPARG | |
| SCHEMBL4685387 | 0.80 | GABRA1 (0.52) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL10701084 | 0.80 | TAAR1 (0.46) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL1930665 | 0.78 | TAAR1 (0.45) | TAAR1IDO1PPARGPPARATSHR | |
| SCHEMBL7666087 | 0.78 | TAAR1 (0.45) | TAAR1IDO1PPARGPPARATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843728-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | Morphic Therapeutic, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047207-A1 | INHIBITORS OF (ALPHA-V)(BETA-6) INTEGRIN | MORPHIC THERAPEUTICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |