Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777390 | 1.00 | MAOA (0.38) | MAOAMAOBMAPTMALT1NPC1 | |
| SCHEMBL29353419 | 0.88 | MAPT (0.34) | MAOAMAOBMAPTMALT1NPC1 | |
| SCHEMBL23496601 | 0.88 | MAOA (0.37) | MAOAMAOBMAPTMALT1NPC1 | |
| SCHEMBL23516874 | 0.87 | MAOA (0.37) | MAOAMAOBMAPTMALT1NPC1 | |
| SCHEMBL30359993 | 0.87 | MAOA (0.37) | MAOAMAOBMAPTMALT1NPC1 | |
| SCHEMBL26710022 | 0.87 | MALT1 (0.43) | MAPTMALT1NPC1RAB9AKMT2A | |
| SCHEMBL29044034 | 0.87 | MAPT (0.34) | MAPTMALT1NPC1LMNARAB9A | |
| SCHEMBL29044032 | 0.87 | MAPT (0.34) | MAPTMALT1NPC1LMNARAB9A | |
| SCHEMBL29351670 | 0.87 | MAPT (0.34) | MAPTMALT1NPC1LMNARAB9A | |
| SCHEMBL29353413 | 0.87 | MAPT (0.34) | MAPTMALT1NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020046941-A1 | CRYSTALLINE FORMS OF SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDE COMPOUNDS AND METHODS OF PREPARING AND USING SAME | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-03-05 | — | — | WO | claimed |
| EP-3601216-B1 | SUBSTITUTED DIHYDROINDENE-4-CARBOXAMIDES AND ANALOGS THEREOF, AND METHODS USING SAME FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTION | ARBUTUS BIOPHARMA CORP (CA) | 2023-10-25 | — | — | EP | disclosed |
| US-20220168430-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | ARBUTUS BIOPHARMA CORPORATION (US) | 2022-06-02 | — | — | US | disclosed |
| WO-2021127214-A1 | SYNTHETIC PROCESSES AND INTERMEDIATES | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-06-24 | — | — | WO | disclosed |
| WO-2020191207-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | ARBUTUS BIOPHARMA CORPORATION (CA) | 2020-09-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220168430-A1 | THERAPEUTIC METHODS FOR TREATING HEPATITIS B | HAVCR2, HDGF, FABP1 | MAOA 2389/4885MAOB 311/4885MAPT 4046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.