Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | MC4R | P32245 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.38 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777405 | 0.86 | ALDH1A1 (0.43) | ALDH1A1EPHX2PPARGPPARAP2RX7 | |
| SCHEMBL21777664 | 0.85 | ITGB3 (0.47) | ALDH1A1EPHX2PPARGPPARAFFAR1 | |
| SCHEMBL21777494 | 0.85 | ITGB3 (0.47) | ALDH1A1EPHX2PPARGPPARAFFAR1 | |
| SCHEMBL6235327 | 0.73 | ALDH1A1 (0.58) | ALDH1A1EPHX2PPARGPPARAFFAR1 | |
| SCHEMBL21789150 | 0.72 | ITGB3 (0.45) | ALDH1A1EPHX2PPARGP2RX7TEAD1 | |
| SCHEMBL21865730 | 0.72 | ITGB3 (0.45) | ALDH1A1EPHX2PPARGP2RX7TEAD1 | |
| SCHEMBL11896375 | 0.70 | HTT (0.43) | ALDH1A1 | |
| SCHEMBL15898200 | 0.70 | HTT (0.40) | ALDH1A1MC4R | |
| SCHEMBL17138252 | 0.69 | HPGD (0.46) | ALDH1A1FFAR1L3MBTL1MC4R | |
| SCHEMBL19650804 | 0.69 | BCHE (0.52) | ALDH1A1EPHX2P2RX7TEAD1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843842-A1 | CARDIAC SARCOMERE INHIBITORS | Cytokinetics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |