Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.43 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.43 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10572282 | 0.88 | KMT2A (0.70) | MEN1KMT2ATDP1CYP1A2CYP2D6 | |
| SCHEMBL21777362 | 0.86 | MEN1 (0.58) | MEN1KMT2ATDP1CYP1A2CYP2D6 | |
| SCHEMBL21788884 | 0.81 | MEN1 (0.53) | MEN1KMT2ATDP1CYP2D6CYP2C19 | |
| SCHEMBL25870931 | 0.80 | MEN1 (0.49) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL1695916 | 0.77 | KMT2A (0.85) | MEN1KMT2ACYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL31173505 | 0.77 | KMT2A (0.85) | MEN1KMT2ACYP2D6CYP2C19ALDH1A1 | |
| SCHEMBL6386453 | 0.75 | KMT2A (0.72) | MEN1KMT2A | |
| SCHEMBL16839854 | 0.75 | KMT2A (0.72) | MEN1KMT2ANPC1RAB9AALDH1A1 | |
| SCHEMBL8231068 | 0.74 | CYP2C19 (0.50) | MEN1KMT2ATDP1CYP1A2CYP2D6 | |
| SCHEMBL15383227 | 0.74 | CYP2C19 (0.50) | MEN1KMT2ATDP1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3843842-A1 | CARDIAC SARCOMERE INHIBITORS | Cytokinetics, Inc. (US) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |