Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777362 | 0.94 | MEN1 (0.58) | MEN1KMT2AL3MBTL1RAB9ACNR2 | |
| SCHEMBL10572282 | 0.87 | KMT2A (0.70) | MEN1KMT2AALDH1A1MAPK1TDP1 | |
| SCHEMBL21777490 | 0.81 | MEN1 (0.61) | MEN1KMT2ARAB9ANPC1ALDH1A1 | |
| SCHEMBL15383227 | 0.76 | CYP2C19 (0.50) | MEN1KMT2AL3MBTL1RAB9ATDP1 | |
| SCHEMBL8231068 | 0.76 | CYP2C19 (0.50) | MEN1KMT2AL3MBTL1RAB9ATDP1 | |
| SCHEMBL31173505 | 0.76 | KMT2A (0.85) | MEN1KMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL1695916 | 0.76 | KMT2A (0.85) | MEN1KMT2AL3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8190393 | 0.75 | L3MBTL1 (0.48) | MEN1KMT2AL3MBTL1ALDH1A1TDP1 | |
| SCHEMBL10833631 | 0.75 | L3MBTL1 (0.64) | MEN1KMT2AL3MBTL1RAB9ANPC1 | |
| SCHEMBL6386453 | 0.74 | KMT2A (0.72) | MEN1KMT2AL3MBTL1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020047447-A1 | CARDIAC SARCOMERE INHIBITORS | CYTOKINETICS, INC. (US) | 2020-03-05 | — | — | WO | disclosed |