Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FUCA1 | P04066 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 3/20 | 0.49 |
| ▸ | BCHE | P06276 | 2/20 | 0.49 |
| ▸ | BACE1 | P56817 | 2/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CCR3 | P51677 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21777836 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL2844733 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL2844736 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21773216 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21777837 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21777260 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL21773211 | 1.00 | FUCA1 (0.53) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL6616536 | 0.93 | FUCA1 (0.50) | FUCA1SIGMAR1DRD2DRD3ACHE | |
| SCHEMBL5071734 | 0.90 | ACHE (0.55) | SIGMAR1DRD2DRD3ACHEBCHE | |
| SCHEMBL4090277 | 0.89 | KDM1A (0.54) | FUCA1SIGMAR1DRD2DRD3ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3844158-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | Xenon Pharmaceuticals Inc. (CA) | 2021-07-07 | — | — | EP | disclosed |
| WO-2020047312-A1 | HETEROARYL-SUBSTITUTED SULFONAMIDE COMPOUNDS AND THEIR USE AS SODIUM CHANNEL INHIBITORS | XENON PHARMACEUTICALS INC. (CA) | 2020-03-05 | — | — | WO | disclosed |